Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Wt1  WT1 transcription factor   (Synonyms: D630046I19Rik, Wilms tumor 1 homolog, Wt-1)
Results	Reference
1	J:263978 Ariza L, Canete A, Rojas A, Munoz-Chapuli R, Carmona R, Role of the Wilms' tumor suppressor gene Wt1 in pancreatic development. Dev Dyn. 2018 Apr 30;
1	J:170930 Asahina K, Zhou B, Pu WT, Tsukamoto H, Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar;53(3):983-95
1	J:328231 Astanina E, Doronzo G, Cora D, Neri F, Oliviero S, Genova T, Mussano F, Middonti E, Vallariello E, Cencioni C, Valdembri D, Serini G, Limana F, Foglio E, Ballabio A, Bussolino F, The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells. Nat Commun. 2022 Sep 3;13(1):5191
1*	J:320610 Auguste D, Maier M, Baldwin C, Aoudjit L, Robins R, Gupta IR, Takano T, Disease-causing mutations of RhoGDIalpha induce Rac1 hyperactivation in podocytes. Small GTPases. 2016 Apr 2;7(2):107-21
1*	J:231312 Baardman ME, Zwier MV, Wisse LJ, Gittenberger-de Groot AC, Kerstjens-Frederikse WS, Hofstra RM, Jurdzinski A, Hierck BP, Jongbloed MR, Berger RM, Plosch T, DeRuiter MC, Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech. 2016 Apr 1;9(4):413-25
1	J:311885 Bandiera R, Vidal VP, Motamedi FJ, Clarkson M, Sahut-Barnola I, von Gise A, Pu WT, Hohenstein P, Martinez A, Schedl A, WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14;27(1):5-18
1	J:208419 Basta JM, Robbins L, Kiefer SM, Dorsett D, Rauchman M, Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58
1*	J:162870 Bax NA, Bleyl SB, Gallini R, Wisse LJ, Hunter J, Van Oorschot AA, Mahtab EA, Lie-Venema H, Goumans MJ, Betsholtz C, Gittenberger-de Groot AC, Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field. Dev Dyn. 2010 Aug;239(8):2307-17
1	J:271989 Bressan M, Henley T, Louie JD, Liu G, Christodoulou D, Bai X, Taylor J, Seidman CE, Seidman JG, Mikawa T, Dynamic Cellular Integration Drives Functional Assembly of the Heart's Pacemaker Complex. Cell Rep. 2018 May 22;23(8):2283-2291
1	J:226657 Callier P, Calvel P, Matevossian A, Makrythanasis P, Bernard P, Kurosaka H, Vannier A, Thauvin-Robinet C, Borel C, Mazaud-Guittot S, Rolland A, Desdoits-Lethimonier C, Guipponi M, Zimmermann C, Stevant I, Kuhne F, Conne B, Santoni F, Lambert S, Huet F, Mugneret F, Jaruzelska J, Faivre L, Wilhelm D, Jegou B, Trainor PA, Resh MD, Antonarakis SE, Nef S, Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling. PLoS Genet. 2014 May;10(5):e1004340
1	J:134687 Chang H, Gao F, Guillou F, Taketo MM, Huff V, Behringer RR, Wt1 negatively regulates {beta}-catenin signaling during testis development. Development. 2008 May;135(10):1875-85
1	J:217615 Chen HI, Poduri A, Numi H, Kivela R, Saharinen P, McKay AS, Raftrey B, Churko J, Tian X, Zhou B, Wu JC, Alitalo K, Red-Horse K, VEGF-C and aortic cardiomyocytes guide coronary artery stem development. J Clin Invest. 2014 Nov;124(11):4899-914
1	J:253680 Chung E, Deacon P, Park JS, Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation. Development. 2017 Dec 15;144(24):4530-4539
1	J:301645 Cleal L, McHaffie SL, Lee M, Hastie N, Martinez-Estrada OM, Chau YY, Resolving the heterogeneity of diaphragmatic mesenchyme: a novel mouse model of congenital diaphragmatic hernia. Dis Model Mech. 2021 Jan 26;14(1)
1	J:171491 Clugston RD, Zhang W, Alvarez S, de Lera AR, Greer JJ, Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia. Am J Respir Cell Mol Biol. 2010 Mar;42(3):276-85
1	J:197449 Coles GL, Ackerman KG, Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1898-905
1	J:270523 Desgrange A, Heliot C, Skovorodkin I, Akram SU, Heikkila J, Ronkainen VP, Miinalainen I, Vainio SJ, Cereghini S, HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis. Development. 2017 Dec 15;144(24):4704-4719
1	J:256264 Diman NY, Brooks G, Kruithof BP, Elemento O, Seidman JG, Seidman CE, Basson CT, Hatcher CJ, Tbx5 is required for avian and Mammalian epicardial formation and coronary vasculogenesis. Circ Res. 2014 Oct 24;115(10):834-44
1	J:225761 Duim SN, Kurakula K, Goumans MJ, Kruithof BP, Cardiac endothelial cells express Wilms' tumor-1: Wt1 expression in the developing, adult and infarcted heart. J Mol Cell Cardiol. 2015 Apr;81:127-35
1	J:290670 Eozenou C, Gonen N, Touzon MS, Jorgensen A, Yatsenko SA, Fusee L, Kamel AK, Gellen B, Guercio G, Singh P, Witchel S, Berman AJ, Mainpal R, Totonchi M, Mohseni Meybodi A, Askari M, Merel-Chali T, Bignon-Topalovic J, Migale R, Costanzo M, Marino R, Ramirez P, Perez Garrido N, Berensztein E, Mekkawy MK, Schimenti JC, Bertalan R, Mazen I, McElreavey K, Belgorosky A, Lovell-Badge R, Rajkovic A, Bashamboo A, Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13680-13688
1	J:245018 Fujii M, Sakaguchi A, Kamata R, Nagao M, Kikuchi Y, Evans SM, Yoshizumi M, Shimono A, Saga Y, Kokubo H, Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle. Nat Commun. 2017 Mar 13;8:14664
1	J:157308 Gai Z, Zhou G, Itoh S, Morimoto Y, Tanishima H, Hatamura I, Uetani K, Ito M, Muragaki Y, Trps1 functions downstream of Bmp7 in kidney development. J Am Soc Nephrol. 2009 Nov;20(11):2403-11
1*	J:111787 Gao F, Maiti S, Alam N, Zhang Z, Deng JM, Behringer RR, Lecureuil C, Guillou F, Huff V, The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11987-92
1*	J:236243 Gittenberger-de Groot AC, Hoppenbrouwers T, Miquerol L, Kosaka Y, Poelmann RE, Wisse LJ, Yost HJ, Jongbloed MR, Deruiter MC, Brunelli L, 14-3-3epsilon controls multiple developmental processes in the mouse heart. Dev Dyn. 2016 Nov;245(11):1107-1123
1	J:292823 Grigorieva IV, Oszwald A, Grigorieva EF, Schachner H, Neudert B, Ostendorf T, Floege J, Lindenmeyer MT, Cohen CD, Panzer U, Aigner C, Schmidt A, Grosveld F, Thakker RV, Rees AJ, Kain R, A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury. J Am Soc Nephrol. 2019 Sep;30(9):1641-1658
1*	J:142456 Gustin SE, Western PS, McClive PJ, Harley VR, Koopman PA, Sinclair AH, Testis development, fertility, and survival in Ethanolamine kinase 2-deficient mice. Endocrinology. 2008 Dec;149(12):6176-86
1	J:263271 Haque F, Rancic V, Zhang W, Clugston R, Ballanyi K, Gosgnach S, WT1-Expressing Interneurons Regulate Left-Right Alternation during Mammalian Locomotor Activity. J Neurosci. 2018 Jun 20;38(25):5666-5676
1	J:338840 Hertig V, Villeneuve L, Calderone A, Nestin identifies a subpopulation of rat ventricular fibroblasts and participates in cell migration. Am J Physiol Cell Physiol. 2023 Aug 1;325(2):C496-C508
1*	J:173795 Hilliard S, Aboudehen K, Yao X, El-Dahr SS, Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching. Dev Biol. 2011 May 15;353(2):354-66
1*	J:315261 Hsu WH, Yu YR, Hsu SH, Yu WC, Chu YH, Chen YJ, Chen CM, You LR, The Wilms' tumor suppressor Wt1 regulates Coronin 1B expression in the epicardium. Exp Cell Res. 2013 Jun 10;319(10):1365-81
1*	J:337240 Huang X, Yan L, Kou S, Meng J, Lu Z, Lin CP, Liu C, Zhang H, Generation and characterization of a Myh6-driven Cre knockin mouse line. Transgenic Res. 2021 Dec;30(6):821-835
1	J:212665 Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ, CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res. 2012 Mar 16;110(6):818-30
1	J:333402 Ihermann-Hella A, Hirashima T, Kupari J, Kurtzeborn K, Li H, Kwon HN, Cebrian C, Soofi A, Dapkunas A, Miinalainen I, Dressler GR, Matsuda M, Kuure S, Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation. Stem Cell Reports. 2018 Oct 9;11(4):912-928
1	J:177490 Jongbloed MR, Vicente-Steijn R, Douglas YL, Wisse LJ, Mori K, Yokota Y, Bartelings MM, Schalij MJ, Mahtab EA, Poelmann RE, Gittenberger-De Groot AC, Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice. Dev Dyn. 2011 Nov;240(11):2561-77
1	J:314319 Kaftanovskaya EM, Neukirchner G, Huff V, Agoulnik AI, Left-sided cryptorchidism in mice with Wilms' tumour 1 gene deletion in gubernaculum testis. J Pathol. 2013 May;230(1):39-47
1	J:158123 Kanazawa T, Konno A, Hashimoto Y, Kon Y, Hepatocyte nuclear factor 4 alpha is related to survival of the condensed mesenchyme in the developing mouse kidney. Dev Dyn. 2010 Apr;239(4):1145-54
1	J:253729 Kelder TP, Duim SN, Vicente-Steijn R, Vegh AM, Kruithof BP, Smits AM, van Bavel TC, Bax NA, Schalij MJ, Gittenberger-de Groot AC, DeRuiter MC, Goumans MJ, Jongbloed MR, The epicardium as modulator of the cardiac autonomic response during early development. J Mol Cell Cardiol. 2015 Dec;89(Pt B):251-9
1	J:128378 Kim BM, Miletich I, Mao J, McMahon AP, Sharpe PA, Shivdasani RA, Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development. 2007 Oct;134(20):3603-13
1*	J:139221 Korostylev A, Worzfeld T, Deng S, Friedel RH, Swiercz JM, Vodrazka P, Maier V, Hirschberg A, Ohoka Y, Inagaki S, Offermanns S, Kuner R, A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis. Development. 2008 Oct;135(20):3333-43
1	J:246806 Li Y, Zhang L, Hu Y, Chen M, Han F, Qin Y, Chen M, Cui X, Duo S, Tang F, Gao F, beta-Catenin directs the transformation of testis Sertoli cells to ovarian granulosa-like cells by inducing Foxl2 expression. J Biol Chem. 2017 Oct 27;292(43):17577-17586
1	J:192186 Maatouk DM, Mork L, Hinson A, Kobayashi A, McMahon AP, Capel B, Germ cells are not required to establish the female pathway in mouse fetal gonads. PLoS One. 2012;7(10):e47238
1*	J:52756 Moore AW, McInnes L, Kreidberg J, Hastie ND, Schedl A, YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development. 1999 May;126(9):1845-57
1	J:156690 Morimoto M, Liu Z, Cheng HT, Winters N, Bader D, Kopan R, Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci. 2010 Jan 15;123(Pt 2):213-24
1	J:222045 Padua MB, Jiang T, Morse DA, Fox SC, Hatch HM, Tevosian SG, Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes. Endocrinology. 2015 May;156(5):1873-86
1	J:227024 Paris ND, Coles GL, Ackerman KG, Wt1 and beta-catenin cooperatively regulate diaphragm development in the mouse. Dev Biol. 2015 Nov 1;407(1):40-56
1	J:225736 Payne S, Burney MJ, McCue K, Popal N, Davidson SM, Anderson RH, Scambler PJ, A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development. Dev Biol. 2015 Sep 1;405(1):82-95
1	J:168399 Perala N, Jakobson M, Ola R, Fazzari P, Penachioni JY, Nymark M, Tanninen T, Immonen T, Tamagnone L, Sariola H, Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney. Differentiation. 2011 Feb;81(2):81-91
1*	J:63188 Piper M, Georgas K, Yamada T, Little M, Expression of the vertebrate slit gene family and their putative receptors, the robo genes, in the developing murine kidney. Mech Dev. 2000 Jun;94(1-2):213-7
1	J:202060 Rakoczy J, Fernandez-Valverde SL, Glazov EA, Wainwright EN, Sato T, Takada S, Combes AN, Korbie DJ, Miller D, Grimmond SM, Little MH, Asahara H, Mattick JS, Taft RJ, Wilhelm D, MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis. Biol Reprod. 2013 Jun;88(6):143
1	J:219551 Rudat C, Norden J, Taketo MM, Kispert A, Epicardial function of canonical Wnt-, Hedgehog-, Fgfr1/2-, and Pdgfra-signalling. Cardiovasc Res. 2013 Dec 1;100(3):411-21
1	J:178172 Sanchez NS, Hill CR, Love JD, Soslow JH, Craig E, Austin AF, Brown CB, Czirok A, Camenisch TD, Barnett JV, The cytoplasmic domain of TGFbetaR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior. Dev Biol. 2011 Oct 15;358(2):331-43
1	J:114384 Schmidt-Ott KM, Chen X, Paragas N, Levinson RS, Mendelsohn CL, Barasch J, c-kit delineates a distinct domain of progenitors in the developing kidney. Dev Biol. 2006 Nov 1;299(1):238-49
1	J:302572 Schnerwitzki D, Hayn C, Perner B, Englert C, Wt1 Positive dB4 Neurons in the Hindbrain Are Crucial for Respiration. Front Neurosci. 2020;14:529487
1	J:287023 Schnerwitzki D, Perry S, Ivanova A, Caixeta FV, Cramer P, Gunther S, Weber K, Tafreshiha A, Becker L, Vargas Panesso IL, Klopstock T, Hrabe de Angelis M, Schmidt M, Kullander K, Englert C, Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord. Life Sci Alliance. 2018 Aug;1(4):e201800106
1	J:343800 Souali-Crespo S, Condrea D, Vernet N, Feret B, Klopfenstein M, Grandgirard E, Alunni V, Cerciat M, Jung M, Mayere C, Nef S, Mark M, Chalmel F, Ghyselinck NB, Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis. Development. 2023 Dec 15;150(24)
1*	J:249296 Spiller CM, Wilhelm D, Koopman P, Retinoblastoma 1 protein modulates XY germ cell entry into G1/G0 arrest during fetal development in mice. Biol Reprod. 2010 Feb;82(2):433-43
1	J:78688 Tevosian SG, Albrecht KH, Crispino JD, Fujiwara Y, Eicher EM, Orkin SH, Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development. 2002 Oct;129(19):4627-34
1*	J:57530 Toyooka Y, Tanaka SS, Hirota O, Tanaka S, Takagi N, Yamanouchi K, Tojo H, Tachi C, Wilms' tumor suppressor gene (WT1) as a target gene of SRY function in a mouse ES cell line transfected with SRY. Int J Dev Biol. 1998 Nov;42(8):1143-51
1	J:317373 Tran JR, Zheng X, Zheng Y, Lamin-B1 contributes to the proper timing of epicardial cell migration and function during embryonic heart development. Mol Biol Cell. 2016 Dec 15;27(25):3956-3963
1	J:217680 Trembley MA, Velasquez LS, de Mesy Bentley KL, Small EM, Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels. Development. 2015 Jan 1;142(1):21-30
1	J:175538 Vega-Hernandez M, Kovacs A, De Langhe S, Ornitz DM, FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium. Development. 2011 Aug;138(15):3331-40
1	J:243174 Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B, Pu WT, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR, Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. PLoS One. 2015;10(9):e0136025
1	J:187162 Wachi T, Yoshida N, Funae Y, Ueno M, Germino GG, Hirotsune S, Deguchi N, Progesterone induced mesenchymal differentiation and rescued cystic dilation of renal tubules of Pkd1(-/-) mice. Biochem Biophys Res Commun. 2012 Aug 24;425(2):212-8
1*	J:185565 Wessels A, van den Hoff MJ, Adamo RF, Phelps AL, Lockhart MM, Sauls K, Briggs LE, Norris RA, van Wijk B, Perez-Pomares JM, Dettman RW, Burch JB, Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart. Dev Biol. 2012 Jun 15;366(2):111-24
1	J:162625 Wu M, Smith CL, Hall JA, Lee I, Luby-Phelps K, Tallquist MD, Epicardial spindle orientation controls cell entry into the myocardium. Dev Cell. 2010 Jul 20;19(1):114-25
1	J:333868 Yan R, Cheng X, Gu C, Xu Y, Long X, Zhai J, Sun F, Qian J, Du Y, Wang H, Guo F, Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development. Nat Genet. 2023 Jan;55(1):130-143
1	J:318865 Zheng B, Zhao D, Zhang P, Shen C, Guo Y, Zhou T, Guo X, Zhou Z, Sha J, Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis. Mol Cell Proteomics. 2015 Oct;14(10):2682-91
1	J:320908 Zheng F, Chen Z, Tang QL, Wang XY, Chong DY, Zhang TY, Gu YY, Hu ZB, Li CJ, Cholesterol metabolic enzyme Ggpps regulates epicardium development and ventricular wall architecture integrity in mice. J Mol Cell Biol. 2021 Sep 11;13(6):445-454